Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development

J Comp Neurol. 2001 Jul 23;436(2):167-81.

Abstract

The Notch-DSL signaling system consists of multiple receptors and ligands, and plays many roles in development. The function of Notch receptors and ligands in mammalian brain, however, is poorly understood. In the current study, we examined the expression patterns for three receptors of this system, Notch1, 2, and 3, in late embryonic and postnatal rat brain by in situ hybridization. The three receptors have overlapping but different patterns of expression. Messenger RNA for all three proteins is found in postnatal central nervous system (CNS) germinal zones and, in early postnatal life, within numerous cells throughout the CNS. Within zones of cellular proliferation of the postnatal brain, Notch1 mRNA is found in both the subventricular and the ventricular germinal zones, whereas Notch2 and Notch3 mRNAs are more highly localized to the ventricular zones. Both Notch1 and Notch3 mRNAs are expressed along the inner aspect of the dentate gyrus, a site of adult neurogenesis. Notch2 mRNA is expressed in the external granule cell layer of the developing cerebellum. In several brain areas, Notch1 and Notch2 mRNAs are relatively concentrated in white matter, whereas Notch3 mRNA is not. Neurosphere cultures (which contain CNS stem cells), purified astrocyte cultures, and striatal neuron-enriched cultures express Notch1 mRNA. However, in these latter cultures, Notch1 mRNA is produced by nestin-containing cells, rather than by postmitotic neurons. Taken together, these results support multiple roles for Notch1, 2, and 3 receptor activation during CNS development, particularly during gliogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Astrocytes / cytology
  • Astrocytes / metabolism
  • Brain / embryology*
  • Brain / growth & development
  • Brain / metabolism
  • Cell Differentiation / genetics*
  • Cells, Cultured
  • Cerebellum / embryology
  • Cerebellum / growth & development
  • Cerebellum / metabolism
  • Fetus
  • Gene Expression Regulation, Developmental / physiology
  • Hippocampus / embryology
  • Hippocampus / growth & development
  • Hippocampus / metabolism
  • Membrane Proteins / genetics*
  • Neocortex / embryology
  • Neocortex / growth & development
  • Neocortex / metabolism
  • Neostriatum / embryology
  • Neostriatum / growth & development
  • Neostriatum / metabolism
  • Nerve Fibers, Myelinated / metabolism
  • Nerve Fibers, Myelinated / ultrastructure
  • Neurons / cytology
  • Neurons / metabolism
  • Proto-Oncogene Proteins / genetics*
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Notch1
  • Receptor, Notch2
  • Receptors, Cell Surface / genetics*
  • Signal Transduction / genetics*
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Transcription Factors*
  • Transforming Growth Factors / genetics*

Substances

  • Membrane Proteins
  • Notch1 protein, rat
  • Notch2 protein, rat
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Receptor, Notch1
  • Receptor, Notch2
  • Receptors, Cell Surface
  • Transcription Factors
  • dorsalin 1 protein, rat
  • Transforming Growth Factors