Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy

Neurol Sci. 2001 Feb;22(1):17-20. doi: 10.1007/s100720170031.

Abstract

We report the case of a 36-year-old woman affected by systemic lupus erythematosus who developed rapidly progressive multifocal leukoencephalopathy. Cidofovir therapy induced disappearance of JC virus genome from the cerebrospinal fluid and stabilization of the MRI picture. Despite the fatal outcome after a few months of disease, cidofovir treatment deserves further testing as single antiviral therapy in HIV-negative PML patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiviral Agents / administration & dosage*
  • Antiviral Agents / adverse effects
  • Brain / drug effects*
  • Brain / pathology
  • Brain / virology
  • Cidofovir
  • Cytosine / administration & dosage*
  • Cytosine / adverse effects
  • Cytosine / analogs & derivatives*
  • DNA, Viral / cerebrospinal fluid*
  • Fatal Outcome
  • Female
  • Humans
  • JC Virus / drug effects*
  • JC Virus / genetics
  • JC Virus / isolation & purification*
  • Leukoencephalopathy, Progressive Multifocal / cerebrospinal fluid
  • Leukoencephalopathy, Progressive Multifocal / drug therapy*
  • Leukoencephalopathy, Progressive Multifocal / virology
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / immunology
  • Magnetic Resonance Imaging
  • Organophosphonates*
  • Organophosphorus Compounds / administration & dosage*
  • Organophosphorus Compounds / adverse effects
  • Renal Insufficiency / immunology
  • Treatment Outcome

Substances

  • Antiviral Agents
  • DNA, Viral
  • Organophosphonates
  • Organophosphorus Compounds
  • Cytosine
  • Cidofovir