Abstract
Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aged
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Antibodies, Neoplasm / blood
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Antigens, Neoplasm / immunology
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Autoantibodies / blood
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Biomarkers, Tumor / blood
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Carcinoma, Small Cell / complications
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Carcinoma, Small Cell / pathology*
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Cerebellar Ataxia / diagnosis*
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Cerebellar Ataxia / etiology
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Cerebellar Ataxia / immunology
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Fatal Outcome
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Female
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Humans
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Lung Neoplasms / complications
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Lung Neoplasms / pathology*
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Nerve Tissue Proteins / immunology
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Optic Nerve Diseases / diagnosis*
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Optic Nerve Diseases / etiology
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Optic Nerve Diseases / immunology
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Paraneoplastic Syndromes / diagnosis*
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Paraneoplastic Syndromes / etiology
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Paraneoplastic Syndromes / immunology
Substances
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Antibodies, Neoplasm
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Antigens, Neoplasm
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Autoantibodies
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Biomarkers, Tumor
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Nerve Tissue Proteins