Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation

J Neurosci Res. 2003 Feb 1;71(3):315-25. doi: 10.1002/jnr.10501.

Abstract

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a critical role in glucose and lipid metabolism. More recently, PPAR-gamma ligands have been reported to inhibit the expression of proinflammatory molecules by monocytes/macrophages. Of relevance to CNS disease is that PPAR-gamma agonists have been demonstrated to have similar effects on microglia. PPAR-gamma agonists also ameliorate experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This Mini-Review summarizes the effects of PPAR-gamma agonists in mediating immune responses and the potential of these agonists in the treatment of inflammatory disorders of the CNS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / immunology
  • Central Nervous System Diseases / metabolism
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / immunology
  • Inflammation / metabolism
  • Macrophages / drug effects
  • Macrophages / immunology
  • Macrophages / metabolism
  • Microglia / drug effects
  • Microglia / immunology
  • Microglia / metabolism
  • Neurons / drug effects
  • Neurons / immunology
  • Neurons / metabolism
  • Receptors, Cytoplasmic and Nuclear / agonists*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Transcription Factors / agonists*
  • Transcription Factors / metabolism

Substances

  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors