Abstract
Background:
Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature.
Case report:
The authors report a patient with anti-Hu associated paraneoplastic sensory neuronopathy who had a spontaneous regression of her small cell lung cancer.
Conclusions:
This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours.
MeSH terms
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Adult
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Antibodies / analysis
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Carcinoma, Small Cell / complications*
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Carcinoma, Small Cell / diagnostic imaging
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Carcinoma, Small Cell / physiopathology*
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ELAV Proteins
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Female
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Humans
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Lung Neoplasms / complications*
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Lung Neoplasms / diagnostic imaging
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Lung Neoplasms / physiopathology*
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Nerve Tissue Proteins / immunology
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Nervous System Diseases / blood
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Nervous System Diseases / complications*
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Nervous System Diseases / immunology
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Paraneoplastic Polyneuropathy / blood
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Paraneoplastic Polyneuropathy / complications*
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Paraneoplastic Polyneuropathy / immunology
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RNA-Binding Proteins / immunology
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Radiography, Thoracic
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Remission, Spontaneous
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Sensation Disorders / blood
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Sensation Disorders / complications*
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Sensation Disorders / immunology
Substances
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Antibodies
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ELAV Proteins
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Nerve Tissue Proteins
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RNA-Binding Proteins