Subthalamic nucleotomy alleviates parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate

T Z Aziz; D Peggs; E Agarwal; M A Sambrook; A R Crossman

doi:10.3109/02688699209002375

Subthalamic nucleotomy alleviates parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate

Br J Neurosurg. 1992;6(6):575-82. doi: 10.3109/02688699209002375.

Authors

T Z Aziz¹, D Peggs, E Agarwal, M A Sambrook, A R Crossman

Affiliation

¹ Department of Cell and Structural Biology, Medical School, Manchester, UK.

PMID: 1361741
DOI: 10.3109/02688699209002375

Abstract

Research into the neural mechanisms underlying the symptoms of parkinsonism utilizing the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate model have shown that the subthalamic nucleus (STN) occupies a central role. As a logical development of this theory, we have studied the effects of thermocoagulative lesions of the STN in the primate model. Such lesions can cause remarkable symptom reversal in the experimental primate model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine*
Animals
Fluorescent Antibody Technique
Macaca fascicularis
Parkinson Disease, Secondary / chemically induced*
Parkinson Disease, Secondary / surgery*
Substantia Nigra / enzymology
Tegmentum Mesencephali / surgery*
Treatment Outcome
Tyrosine 3-Monooxygenase / analysis

Substances

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Tyrosine 3-Monooxygenase