Abstract
The authors propose that patients who suffer from migraine with aura have a susceptibility to spontaneous neuronal discharges and subsequent spreading depression. This is based upon a state of central neuronal excitability involving the excitatory neurotransmitter glutamate, in combination with supersensitivity of the N-méthyl-D-aspartate (NMDA) receptor. This hypersusceptibility is supported by increased turnover of high-energy phosphates, low intracellular Mg2+ and large amplitude depolarizing waves on magnetoencephalography (MEG).
MeSH terms
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Cortical Spreading Depression / physiology*
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Energy Metabolism / physiology
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Humans
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Hydrogen-Ion Concentration
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Ischemic Attack, Transient / complications
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Ischemic Attack, Transient / metabolism
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Magnesium / metabolism
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Magnetic Resonance Spectroscopy / methods*
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Magnetoencephalography / methods*
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Migraine Disorders / diagnostic imaging*
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Migraine Disorders / etiology
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Migraine Disorders / metabolism
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Migraine Disorders / physiopathology
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Phosphates / metabolism
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Phosphocreatine / metabolism
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Radiography
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Reference Values
Substances
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Phosphates
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Phosphocreatine
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Magnesium