The ability of self-efficacy (SE) and outcome expectations (OE) to predict adjustment to multiple sclerosis (MS) was explored. A sample of 62 respondents who had MS was used to test study hypotheses. Self-efficacy expectations predicted 24% of the variance in adjustment to chronic physical illness. Outcome expectations did not significantly add to the predictive power of SE. However, the model containing SE, OE and degree of disability predicted 51% of the variance in adjustment.