Abstract
The authors prospectively treated 18 consecutive patients with low-grade oligodendroglial tumors without postoperative radiotherapy. The treatment strategy was as follows: follow-up after total resection and chemotherapy after subtotal resection or biopsy. All patients were alive and 17 patients (94%) were progression-free after a median follow-up of 4.7 years. The results suggested that radiotherapy could be postponed until clinical progression in the treatment of low-grade oligodendroglial tumors.
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Biopsy
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / mortality
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Brain Neoplasms / pathology
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Brain Neoplasms / surgery
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Combined Modality Therapy
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Disease-Free Survival
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Female
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Follow-Up Studies
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Humans
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Life Tables
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Male
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Middle Aged
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Neoplasm Recurrence, Local
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Nimustine / administration & dosage
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Oligodendroglioma / drug therapy*
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Oligodendroglioma / mortality
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Oligodendroglioma / pathology
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Oligodendroglioma / surgery
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Procarbazine / administration & dosage
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Prospective Studies
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Survival Analysis
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Treatment Outcome
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Vincristine / administration & dosage
Substances
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Nimustine
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Procarbazine
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Vincristine