Abstract
8-hydroxydeoxyguanosine (8-OHdG) has been used to evaluate oxidative stress. The authors investigated urinary 8-OHdG levels in 72 patients with Parkinson disease (PD) and in normal and disease control groups. The mean urinary 8-OHdG increased with the stage of PD and was not influenced by the current dose of DOPA. Our results suggest that urinary 8-OHdG is a potentially useful biomarker for evaluating the progression of PD.
MeSH terms
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8-Hydroxy-2'-Deoxyguanosine
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Adult
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Aged
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Aged, 80 and over
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Biomarkers / urine
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Brain / drug effects
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Brain / metabolism*
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Brain / physiopathology
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Creatinine / urine
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Deoxyguanosine / analogs & derivatives*
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Deoxyguanosine / urine
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Dihydroxyphenylalanine / administration & dosage
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Disease Progression
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Dopamine Agents / administration & dosage
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Dose-Response Relationship, Drug
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Male
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Middle Aged
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Oxidative Stress / physiology*
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Parkinson Disease / diagnosis*
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Parkinson Disease / drug therapy
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Parkinson Disease / urine*
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Predictive Value of Tests
Substances
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Biomarkers
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Dopamine Agents
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Dihydroxyphenylalanine
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8-Hydroxy-2'-Deoxyguanosine
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Creatinine
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Deoxyguanosine