Abstract
In a hereditary variant of cerebral amyloid angiopathy (CAA), cerebral hemorrhage with amyloidosis-Dutch type, supratentorial microbleeds were found to occur independently of the presence of hypertension, whereas hypertension probably contributed to the development of cerebellar microbleeds. This predictable hereditary variant of CAA may be a useful model to study microbleeds in relation to CAA.
MeSH terms
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Adult
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Age Factors
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Apolipoprotein E4
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Apolipoproteins E / genetics
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Brain / blood supply
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Brain / pathology
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Brain / physiopathology
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Causality
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Cerebral Amyloid Angiopathy, Familial / diagnosis*
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Cerebral Amyloid Angiopathy, Familial / genetics
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Cerebral Amyloid Angiopathy, Familial / physiopathology
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Cerebral Arteries / metabolism
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Cerebral Arteries / pathology
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Cerebral Arteries / physiopathology
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Cerebral Hemorrhage / diagnosis*
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Cerebral Hemorrhage / epidemiology*
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Cerebral Hemorrhage / genetics
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Comorbidity
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DNA Mutational Analysis
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Female
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genotype
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Humans
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Hypertension / diagnosis
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Hypertension / epidemiology*
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Hypertension / genetics
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Mutation / genetics
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Sex Factors
Substances
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Apolipoprotein E4
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Apolipoproteins E