Semantic memory impairment in Alzheimer's disease: failure of access or degraded knowledge?

Neuropsychologia. 1992 Apr;30(4):301-14. doi: 10.1016/0028-3932(92)90104-t.

Abstract

A battery of neuropsychological tests designed to assess semantic knowledge about the same items both within and across different modalities was administered to a group of 22 patients with dementia of the Alzheimer type (DAT) and 26 matched controls. The DAT patients were impaired on tests of category fluency, picture naming, spoken word-picture matching, picture sorting and generation of verbal definitions. A relative preservation of superordinate knowledge on the sorting and definition tests, as well as a disproportionate reduction in the generation of exemplars from lower order categories was noted. Analysis of the errors made by each patient across the different tests, revealed a significant correspondence between the individual items. These findings offer compelling evidence that the semantic breakdown in DAT is caused by storage degradation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / psychology*
  • Anomia / diagnosis
  • Anomia / psychology
  • Female
  • Humans
  • Male
  • Mental Recall*
  • Neuropsychological Tests*
  • Paired-Associate Learning
  • Prospective Studies
  • Reaction Time
  • Retention, Psychology*
  • Semantics*
  • Verbal Learning*