Abstract
A 60-year-old man presented with slowly progressive left hemi-Parkinsonism, left hand apraxia, myoclonus, dystonia, visuospatial disturbances, and alien limb phenomenon, resembling corticobasal syndrome. Eight years later, neuropathology revealed features of Alzheimer's disease, with asymmetrical (right more than left) cortical tau burden with image analysis. The videotaped clinical features, neuropsychological aspects, and neuropathological correlates are presented and discussed.
MeSH terms
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Alzheimer Disease / complications*
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Alzheimer Disease / metabolism
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Alzheimer Disease / pathology
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Basal Ganglia Diseases / etiology*
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Basal Ganglia Diseases / pathology
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Cerebral Amyloid Angiopathy / pathology
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Functional Laterality
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Hand / physiopathology
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Humans
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Male
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Middle Aged
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Myoclonus / etiology
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Neurodegenerative Diseases / etiology*
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Neurodegenerative Diseases / metabolism
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Neuropsychological Tests
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Plaque, Amyloid / pathology
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Supranuclear Palsy, Progressive / etiology
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tau Proteins / metabolism