Abstract
We studied seroprevalence and concentrations of Epstein-Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antibodies, Viral / blood
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Child
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Child, Preschool
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Cohort Studies
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Epstein-Barr Virus Infections / epidemiology
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Epstein-Barr Virus Infections / virology
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Female
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Germany / epidemiology
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Herpesvirus 4, Human / isolation & purification*
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Herpesvirus 4, Human / metabolism
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Humans
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Longitudinal Studies
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Male
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Multiple Sclerosis / epidemiology
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Multiple Sclerosis / virology*
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Seroepidemiologic Studies