Abstract
Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year. Carbamazepine in moderate dosage adversely affected memory, but sodium valproate and phenytoin did not.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Anticonvulsants / adverse effects
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Anticonvulsants / blood
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Anticonvulsants / therapeutic use*
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Carbamazepine / therapeutic use
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Child
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Child, Preschool
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Cognition / drug effects*
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Epilepsy / drug therapy*
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Epilepsy / psychology
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Humans
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Intelligence Tests
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Phenytoin / therapeutic use
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Random Allocation
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Valproic Acid / therapeutic use
Substances
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Anticonvulsants
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Carbamazepine
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Valproic Acid
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Phenytoin