Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia

Wataru Sako; Satoshi Goto; Hideki Shimazu; Nagako Murase; Kazuhito Matsuzaki; Tetsuya Tamura; Hideo Mure; Yusuke Tomogane; Norio Arita; Hiroo Yoshikawa; Shinji Nagahiro; Ryuji Kaji

doi:10.1002/mds.22100

Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia

Mov Disord. 2008 Oct 15;23(13):1929-31. doi: 10.1002/mds.22100.

Authors

Wataru Sako¹, Satoshi Goto, Hideki Shimazu, Nagako Murase, Kazuhito Matsuzaki, Tetsuya Tamura, Hideo Mure, Yusuke Tomogane, Norio Arita, Hiroo Yoshikawa, Shinji Nagahiro, Ryuji Kaji

Affiliation

¹ Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.

PMID: 18785227
DOI: 10.1002/mds.22100

Abstract

Tardive dystonia is a disabling movement disorder as a consequence of exposure to neuroleptic drugs. We followed 6 patients with medically refractory tardive dystonia treated by bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for 21 +/- 18 months. At last follow-up, the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor score improved by 86% +/- 14%, and the BFMDRS disability score improved by 80% +/- 12%. Bilateral GPi-DBS is a beneficial therapeutic option for the long-term relief of tardive dystonia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Biophysics
Deep Brain Stimulation / methods*
Dystonia / therapy*
Female
Globus Pallidus / physiology*
Humans
Male
Middle Aged
Treatment Outcome