Abstract
Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar beta-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amyloid beta-Peptides / analysis*
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Aniline Compounds*
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Brain / diagnostic imaging*
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Brain / metabolism*
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Brain / physiopathology
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Brain Mapping / methods
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Cerebral Amyloid Angiopathy / diagnostic imaging*
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Cerebral Amyloid Angiopathy / metabolism*
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Cerebral Amyloid Angiopathy / physiopathology
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Cerebral Arteries / metabolism
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Cerebral Arteries / pathology
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Cerebral Arteries / physiopathology
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Humans
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Male
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Occipital Lobe / diagnostic imaging
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Occipital Lobe / metabolism
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Occipital Lobe / physiopathology
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Plaque, Amyloid / diagnostic imaging
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Plaque, Amyloid / metabolism
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Plaque, Amyloid / pathology
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Positron-Emission Tomography / methods
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Predictive Value of Tests
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Thiazoles*
Substances
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2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
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Amyloid beta-Peptides
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Aniline Compounds
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Thiazoles