A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

Nat Genet. 2009 Aug;41(8):876-8. doi: 10.1038/ng.417. Epub 2009 Jul 13.

Abstract

We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Atrial Fibrillation / complications
  • Atrial Fibrillation / genetics*
  • Base Sequence
  • Brain Ischemia / complications
  • Brain Ischemia / genetics*
  • Chromosomes, Human, Pair 16 / genetics*
  • Genetic Predisposition to Disease*
  • Homeodomain Proteins / genetics*
  • Humans
  • Mutation / genetics*
  • Stroke / complications
  • Stroke / genetics*

Substances

  • Homeodomain Proteins
  • ZFHX3 protein, human