Neuroleptic malignant syndrome and acute motor axonal neuropathy after Campylobacter jejuni infection

Neurophysiol Clin. 2009 Aug;39(3):135-8. doi: 10.1016/j.neucli.2009.02.001. Epub 2009 Mar 17.

Abstract

We report the case of a patient with Parkinson's disease who developed rapidly progressive weakness of the four limbs due to an acute motor axonal neuropathy (AMAN). This occurred days after a neuroleptic malignant syndrome (NMS). Serologic evidence of a preceding Campylobacter jejuni infection was detected and treatment with intravenous immunoglobulins proved effective. This case suggests that the rarely described neuropathies occurring with NMS may have a postinfectious immune basis and respond to immunomodulatory therapy.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Bacterial / blood
  • Antibodies, Bacterial / immunology
  • Antiparkinson Agents / adverse effects
  • Antiparkinson Agents / therapeutic use
  • Campylobacter Infections / complications*
  • Campylobacter Infections / diagnosis
  • Campylobacter jejuni*
  • Electromyography
  • Fever / etiology
  • G(M1) Ganglioside / immunology
  • Guillain-Barre Syndrome / etiology*
  • Guillain-Barre Syndrome / therapy
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / immunology
  • Immunoglobulin M / blood
  • Immunoglobulin M / immunology
  • Immunoglobulins, Intravenous / therapeutic use
  • Lipopolysaccharides / immunology
  • Male
  • Middle Aged
  • Molecular Mimicry
  • Neural Conduction
  • Neuroleptic Malignant Syndrome / etiology*
  • Parkinson Disease / complications*
  • Parkinson Disease / drug therapy
  • Quadriplegia / etiology*
  • Unconsciousness / etiology

Substances

  • Antibodies, Bacterial
  • Antiparkinson Agents
  • Immunoglobulin G
  • Immunoglobulin M
  • Immunoglobulins, Intravenous
  • Lipopolysaccharides
  • G(M1) Ganglioside