Evidence for a dissociation between perceptual and conceptual priming in Alzheimer's disease

Behav Neurosci. 1991 Apr;105(2):326-42. doi: 10.1037//0735-7044.105.2.326.

Abstract

The status of perceptual priming and word-completion priming in patients with Alzheimer's disease (AD) was examined. Experiment 1 established the reliability of the perceptual priming measure in normal subjects. In Experiment 2, AD patients showed a normal magnitude of perceptual priming. In Experiment 3, a single group of AD patients showed a normal magnitude of perceptual priming and impaired word-completion priming. Further, word-completion priming, but not perceptual priming, was correlated with verbal fluency performance in AD. These results suggest a dissociation between two components of verbal priming. Perceptual priming may reflect the operation of a structural-perceptual memory system mediated by occipital lobe regions relatively spared in AD. Word-completion priming may reflect the operation of a lexical-semantic memory system mediated by temporoparietal lobe regions compromised in AD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / physiopathology*
  • Alzheimer Disease / psychology
  • Attention / physiology*
  • Concept Formation / physiology*
  • Female
  • Humans
  • Male
  • Mental Recall / physiology*
  • Middle Aged
  • Neurons / physiology
  • Neuropsychological Tests
  • Occipital Lobe / physiopathology
  • Semantics
  • Verbal Learning / physiology*
  • Visual Perception / physiology*