Abstract
We report a patient with anti-myelin-associated glycoprotein (MAG) neuropathy, predominantly exhibiting severe motor symptoms, accompanied by extensive muscle atrophy mimicking Charcot-Marie-Tooth disease. Nerve conduction studies revealed mild retardation of motor conduction velocities and significant prolongation of distal latency. Sural nerve biopsy revealed widely spaced myelin and positive staining of myelinated fibers with an IgM antibody. Predominant motor symptoms with muscle atrophy can be one of the clinical manifestations of anti-MAG neuropathy.
MeSH terms
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Charcot-Marie-Tooth Disease / pathology
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Diagnosis, Differential
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Electrodiagnosis
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Humans
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Immunoglobulin M* / blood
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Immunoglobulins, Intravenous / therapeutic use
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Lower Extremity / pathology
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Male
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Middle Aged
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Muscle Weakness / etiology
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Muscle Weakness / pathology*
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Muscle Weakness / therapy
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Muscle, Skeletal / pathology*
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Muscular Atrophy
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Myelin-Associated Glycoprotein / immunology*
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Neural Conduction / physiology
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Paraproteinemias / pathology*
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Paraproteinemias / therapy
Substances
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Immunoglobulin M
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Immunoglobulins, Intravenous
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Myelin-Associated Glycoprotein