Methotrexate sensitivity in Down's syndrome: a hypothesis

Cancer Chemother Pharmacol. 1990;25(5):384-6. doi: 10.1007/BF00686245.

Authors

P M Ueland¹, H Refsum, B Christensen

Affiliation

¹ Department of Pharmacology and Toxicology, University of Bergen, Norway.

PMID: 2137726
DOI: 10.1007/BF00686245

No abstract available

MeSH terms

Down Syndrome / complications*
Down Syndrome / metabolism
Drug Tolerance
Folic Acid Antagonists
Homocysteine / metabolism
Humans
Methotrexate / adverse effects*
Methotrexate / therapeutic use
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*

Substances

Folic Acid Antagonists
Homocysteine
Methotrexate