Milestones in atypical and secondary Parkinsonisms

Mov Disord. 2011 May;26(6):1083-95. doi: 10.1002/mds.23713.

Abstract

During the last decades, atypical parkinsonian disorders such as multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy, and corticobasal degeneration along with secondary parkinsonian disorders have been increasingly recognized as important causes of parkinsonism. Although treatment options are largely limited to date, remarkable progress has occurred through advances in the fields of molecular biology and diagnostic neuroimaging, resulting in intense preclinical drug discovery programs. Early-investigation-assisted clinical diagnosis has become more crucial than ever because disease-modifying therapies will hopefully become available within this decade.

Publication types

  • Historical Article
  • Review

MeSH terms

  • History, 19th Century
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Lewy Body Disease / diagnosis
  • Lewy Body Disease / epidemiology
  • Lewy Body Disease / genetics
  • Multiple System Atrophy / diagnosis
  • Multiple System Atrophy / epidemiology
  • Multiple System Atrophy / genetics
  • Neurodegenerative Diseases / diagnosis
  • Neurodegenerative Diseases / epidemiology
  • Neurodegenerative Diseases / genetics
  • Parkinson Disease, Secondary / diagnosis*
  • Parkinson Disease, Secondary / epidemiology
  • Parkinson Disease, Secondary / history*
  • Parkinson Disease, Secondary / physiopathology*
  • Supranuclear Palsy, Progressive / diagnosis
  • Supranuclear Palsy, Progressive / epidemiology
  • Supranuclear Palsy, Progressive / genetics