Abstract
A variety of neurotransmitters have been implicated in the pathophysiology of chorea as exemplified by Huntington's chorea. These include dopamine, serotonin, acetylcholine, GABA and a variety of neuropeptides including substance P and somatostatin. Despite biochemical data that suggests that alterations in other neurotransmitters may be of greater significance, pharmacologic data still supports a major role of dopamine in the actual clinical manifestation of chorea.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antipsychotic Agents / therapeutic use
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Cholinergic Fibers / physiopathology
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Chorea / drug therapy
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Chorea / metabolism*
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Chorea / physiopathology
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Corpus Striatum / metabolism*
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Corpus Striatum / physiopathology
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Dopamine / metabolism*
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Humans
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Huntington Disease / drug therapy
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Huntington Disease / metabolism
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Huntington Disease / physiopathology
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Levodopa
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Reserpine / therapeutic use
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Serotonin / metabolism
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Somatostatin / metabolism
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Substance P / metabolism
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gamma-Aminobutyric Acid / metabolism
Substances
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Antipsychotic Agents
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Serotonin
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Substance P
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Levodopa
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Somatostatin
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gamma-Aminobutyric Acid
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Reserpine
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Dopamine