Dopaminergic modulation of striatal networks in health and Parkinson's disease

D James Surmeier; Steven M Graves; Weixing Shen

doi:10.1016/j.conb.2014.07.008

Dopaminergic modulation of striatal networks in health and Parkinson's disease

Curr Opin Neurobiol. 2014 Dec:29:109-17. doi: 10.1016/j.conb.2014.07.008. Epub 2014 Jul 22.

Authors

D James Surmeier¹, Steven M Graves², Weixing Shen²

Affiliations

¹ Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: j-surmeier@northwestern.edu.
² Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Abstract

In the last couple of years, there have been significant advances in our understanding of how dopamine modulates striatal circuits underlying goal-directed behaviors and how therapeutic interventions intended to normalize disordered dopaminergic signaling can go awry. This review summarizes some of the advances in this field with a translational focus on Parkinson's disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Corpus Striatum / metabolism
Corpus Striatum / pathology*
Dopamine / metabolism*
Humans
Nerve Net / metabolism*
Parkinson Disease / pathology*
Signal Transduction / physiology

Substances

Dopamine

Abstract

Publication types

MeSH terms

Substances

Grants and funding