Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

Y Mizuno; S Ohta; M Tanaka; S Takamiya; K Suzuki; T Sato; H Oya; T Ozawa; Y Kagawa

doi:10.1016/0006-291x(89)91141-8

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

Biochem Biophys Res Commun. 1989 Sep 29;163(3):1450-5. doi: 10.1016/0006-291x(89)91141-8.

Authors

Y Mizuno¹, S Ohta, M Tanaka, S Takamiya, K Suzuki, T Sato, H Oya, T Ozawa, Y Kagawa

Affiliation

¹ Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.

PMID: 2551290
DOI: 10.1016/0006-291x(89)91141-8

Abstract

Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease. Deficiencies in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Corpus Striatum / enzymology*
Electron Transport Complex III / isolation & purification
Electron Transport Complex IV / isolation & purification
Humans
Immunoblotting
Macromolecular Substances
Mitochondria / enzymology*
NAD(P)H Dehydrogenase (Quinone)
Oxygen Consumption
Parkinson Disease / enzymology*
Quinone Reductases / deficiency*
Quinone Reductases / isolation & purification
Quinone Reductases / metabolism
Reference Values

Substances

Macromolecular Substances
NAD(P)H Dehydrogenase (Quinone)
Quinone Reductases
Electron Transport Complex IV
Electron Transport Complex III