Development of platelets during steady state and inflammation

Gerhard Müller-Newen; Matthias B Stope; Thomas Kraus; Patrick Ziegler

doi:10.1189/jlb.1RU0916-391RR

Development of platelets during steady state and inflammation

J Leukoc Biol. 2017 May;101(5):1109-1117. doi: 10.1189/jlb.1RU0916-391RR. Epub 2017 Feb 24.

Authors

Gerhard Müller-Newen¹, Matthias B Stope², Thomas Kraus³, Patrick Ziegler⁴

Affiliations

¹ Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Aachen, Germany.
² Department of Urology, University Medicine, Greifswald, Germany.
³ Institute for Occupational and Social Medicine, RWTH Aachen University, Aachen, Germany.
⁴ Institute for Occupational and Social Medicine, RWTH Aachen University, Aachen, Germany pziegler@ukaachen.de.

PMID: 28235774
DOI: 10.1189/jlb.1RU0916-391RR

Abstract

Megakaryocytes (MK) are the sole source of platelets in the body. They develop from lineage-committed hematopoietic stem and progenitor cells (HSPCs) via intermediate cells, which differ in morphology, size, ploidy, and surface phenotype. Development and maturation of MKs is governed by different transcription factors, including GATA-1, E26 transformation-specific transcription factor (ETS) family members, nuclear factor erythroid 2 transcription factor (NF-E2), and STAT3. During such challenges as acute inflammation, platelets are consumed in high numbers and must be replenished to secure survival of the host. This is achieved by integration of inflammatory signals into early MK development and depends on the STAT1-mediated enhanced translation of transcripts in stem cell-like megakaryocyte progenitors. Here, we review recent developments, which highlight the impact of inflammation on the development of platelets from HSPCs.

Keywords: emergency megakaryopoiesis; hematopoietic progenitor cells; interferon.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Platelets / cytology
Blood Platelets / immunology*
Cell Differentiation
Cell Lineage / immunology
Cell Proliferation
Cytokines / genetics
Cytokines / immunology*
GATA1 Transcription Factor / genetics
GATA1 Transcription Factor / immunology
Gene Expression Regulation, Developmental / immunology*
Hematopoietic Stem Cells / cytology
Hematopoietic Stem Cells / immunology*
Humans
Inflammation / genetics
Inflammation / immunology*
Inflammation / pathology
Megakaryocytes / cytology
Megakaryocytes / immunology*
Mice
NF-E2 Transcription Factor, p45 Subunit / genetics
NF-E2 Transcription Factor, p45 Subunit / immunology
Proto-Oncogene Proteins c-ets / genetics
Proto-Oncogene Proteins c-ets / immunology
STAT Transcription Factors / genetics
STAT Transcription Factors / immunology
Signal Transduction

Substances

Cytokines
GATA1 Transcription Factor
GATA1 protein, human
NF-E2 Transcription Factor, p45 Subunit
NFE2 protein, human
Proto-Oncogene Proteins c-ets
STAT Transcription Factors