Abstract
A diminution of the mitotic index, proportionnal to the square of the dose of methotrexate, was observed in lymphocyte cultures. Six trisomy 21 patients were twice as sensitive as six controls. This highly significant result confirms the hypothesis of a disturbance of monocarbons' metabolism in trisomy 21.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Cells, Cultured
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Dose-Response Relationship, Drug
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Down Syndrome / blood*
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Homocysteine / pharmacology
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Humans
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Lymphocytes / drug effects*
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Lymphocytes / pathology
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Methionine / pharmacology
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Methotrexate / pharmacology*
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Mitotic Index / drug effects
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Purines / biosynthesis
Substances
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Purines
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Homocysteine
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Methionine
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Methotrexate