Five observations characterized by an isolated topographical disorientation without any intellectual impairment are reported. One was associated to a topographical confabulation. Aetiological data and clinical associations are discussed. In three cases, the site of lesion, as indicated by surgery and CT Scan, involves the posterior part of the right hemisphere. The occurrence of this syndrome may be ascribed to three possible factors: amnesia (topographical amnesia) agnosia (topographical agnosia) and apraxia.