Abstract
The lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12/Notch family of receptors for intercellular signals that specify cell fate. By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1. The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to S182, which has been implicated in early-onset familial Alzheimer's disease. The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alleles
-
Alzheimer Disease / genetics*
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Caenorhabditis elegans / genetics*
-
Caenorhabditis elegans Proteins*
-
Conserved Sequence
-
DNA Primers
-
Female
-
Genes, Helminth
-
Helminth Proteins / genetics*
-
Helminth Proteins / metabolism
-
Humans
-
Membrane Proteins / genetics*
-
Membrane Proteins / metabolism
-
Molecular Sequence Data
-
Mutagenesis
-
Receptors, Notch
-
Signal Transduction*
-
Suppression, Genetic
-
Vulva / embryology
Substances
-
Caenorhabditis elegans Proteins
-
DNA Primers
-
Helminth Proteins
-
Lin-12 protein, C elegans
-
Membrane Proteins
-
Receptors, Notch
-
SEL-12 protein, C elegans