We have examined the effects of a transcranial magnetic stimulus (TMS) on the H reflex of the soleus muscle during vibration-induced presynaptic inhibition of the reflex, in seven normal volunteers. Without vibration, the H reflex was facilitated at interstimulus time intervals of > or = 5 ms after TMS. With vibration, the H reflex was markedly reduced or completely inhibited in control trials, but facilitation by TMS was noticed at intervals as short as -2.5 ms. These findings indicate an effect of TMS on the spinal interneurons mediating presynaptic vibratory inhibition of the H reflex.