Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus)

J Staedt; G Stoppe; A Kögler; D Munz; H Riemann; D Emrich; E Rüther

doi:10.1007/BF01244940

Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus)

J Neural Transm Gen Sect. 1993;93(1):71-4. doi: 10.1007/BF01244940.

Authors

J Staedt¹, G Stoppe, A Kögler, D Munz, H Riemann, D Emrich, E Rüther

Affiliation

¹ Department of Psychiatry, Georg August University, Göttingen, Federal Republic of Germany.

PMID: 8103994
DOI: 10.1007/BF01244940

Abstract

Periodic movements in sleep (PMS) can cause severe sleep disturbances. We investigated the central dopamine D2 receptor density in patients with PMS with 123I-IBZM and single photon emission tomography (SPET). In PMS there was a lower 123I-IBZM binding in the basal ganglia compared to the control group. The results indicate a loss of central D2 receptors in PMS.

MeSH terms

Adult
Aged
Corpus Striatum / diagnostic imaging
Dopamine Agents / therapeutic use
Female
Humans
Male
Middle Aged
Myoclonus / diagnostic imaging
Myoclonus / drug therapy
Myoclonus / metabolism*
Periodicity*
Receptors, Dopamine D2 / metabolism*
Sleep Wake Disorders / diagnostic imaging
Sleep Wake Disorders / drug therapy
Sleep Wake Disorders / metabolism*
Tomography, Emission-Computed, Single-Photon

Substances

Dopamine Agents
Receptors, Dopamine D2