Hereditary spastic paraplegia associated with epilepsy, mental retardation and hearing impairment

J S Yih; S J Wang; M S Su; S C Tsai; R H Lin; K N Lin; H C Liu

doi:10.1038/sc.1993.68

Hereditary spastic paraplegia associated with epilepsy, mental retardation and hearing impairment

Paraplegia. 1993 Jun;31(6):408-11. doi: 10.1038/sc.1993.68.

Authors

J S Yih¹, S J Wang, M S Su, S C Tsai, R H Lin, K N Lin, H C Liu

Affiliation

¹ Neurological Institute, Veterans General Hospital-Taipei, Taiwan, Republic of China.

PMID: 8337006
DOI: 10.1038/sc.1993.68

Abstract

Epilepsy rarely occurs in patients with hereditary spastic paraplegia (HSP), and is not included in the description of the 'complicated' form of HSP by Harding. We report 3 patients with HSP in a family of two generations. Two of them also had epilepsy, mental retardation and hearing impairment. The disorder was inherited as an autosomal dominant trait.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Electroencephalography
Epilepsy / complications*
Epilepsy / genetics
Family
Female
Hearing Disorders / complications*
Hearing Disorders / genetics
Humans
Intellectual Disability / complications*
Intellectual Disability / genetics
Male
Neural Conduction / physiology
Spastic Paraplegia, Hereditary / complications*
Spastic Paraplegia, Hereditary / genetics