Abstract
To clarify cortical lesions responsible for apraxia in cortico-basal degeneration (CBD), we reconstructed three-dimensional surface images from single-photon emission computed tomography (SPECT) data with N-isopropyl-p[I-123]-iodoamphetamine in two patients with CBD. Both had limb-kinetic apraxia (LKA) and one also had constructional apraxia (CA). Both showed asymmetrical cortical hypoperfusion in the perirolandic area. The patient with CA had unilateral hypoperfusion in the posterior parietal area. Thus, cortical hypoperfusion in the perirolandic area corresponded to LKA, and that in the posterior parietal area to CA.
MeSH terms
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Aged
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Amphetamines
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Basal Ganglia / blood supply
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Basal Ganglia / diagnostic imaging
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Basal Ganglia / physiopathology
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Basal Ganglia Diseases / diagnostic imaging*
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Basal Ganglia Diseases / physiopathology
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Brain Ischemia / diagnostic imaging*
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Brain Ischemia / physiopathology
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Cerebral Cortex / blood supply*
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Cerebral Cortex / diagnostic imaging
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Cerebral Cortex / physiopathology
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Diagnosis, Differential
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Dominance, Cerebral / physiology
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Female
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Frontal Lobe / blood supply
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Frontal Lobe / diagnostic imaging
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Frontal Lobe / physiopathology
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Humans
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Image Processing, Computer-Assisted*
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Iodine Radioisotopes
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Iofetamine
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Male
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Nerve Degeneration / physiology*
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Neurologic Examination
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Tomography, Emission-Computed, Single-Photon*
Substances
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Amphetamines
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Iodine Radioisotopes
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Iofetamine