Abstract
We studied the effect of an acute loading dose of vigabatrin on threshold of motor responses and duration of silent period elicited with cortical magnetic stimulation in normal subjects. In contrast to phenytoin, vigabatrin does not increase the motor threshold of first dorsal interosseus muscle. We also show that, although vigabatrin increases GABA concentrations in the central nervous system, duration of silent period studied at various stimulus intensities is not modified after vigabatrin administration.
Publication types
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Clinical Trial
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anticonvulsants / pharmacology*
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Differential Threshold / drug effects
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Electromyography
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Evoked Potentials, Motor / drug effects*
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Hand
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Humans
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Magnetics
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Male
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Middle Aged
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Muscles / physiology
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Phenytoin / pharmacology
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Physical Stimulation
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Vigabatrin
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gamma-Aminobutyric Acid / analogs & derivatives*
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gamma-Aminobutyric Acid / pharmacology
Substances
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Anticonvulsants
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gamma-Aminobutyric Acid
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Phenytoin
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Vigabatrin