Abstract
The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique transport properties of the holotoxin and is capable of eliciting a protective immunological response against the full length holotoxin.
Publication types
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Comparative Study
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Letter
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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Computer Simulation
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Crystallography, X-Ray
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Membrane Proteins / chemistry*
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Membrane Proteins / metabolism
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Models, Molecular
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Models, Structural
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Molecular Sequence Data
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Neurons / metabolism
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Peptide Fragments / chemistry
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Peptide Fragments / immunology
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Protein Structure, Secondary*
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Sequence Deletion
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Software
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Tetanus Toxin / chemistry*
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Tetanus Toxin / immunology
Substances
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Membrane Proteins
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Peptide Fragments
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Tetanus Toxin
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tetanus toxin receptor