Abstract
A 44-year-old man developed a peripheral neuropathy during treatment with interferon-alpha for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Axons / physiology
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Fluorescent Antibody Technique, Direct
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HLA-DR Antigens / metabolism*
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Hepatitis C / complications*
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Hepatitis C / drug therapy
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Humans
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Immunohistochemistry
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Interferon Type I / adverse effects*
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Interferon Type I / therapeutic use
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Male
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Nerve Fibers, Myelinated / physiology
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Nerve Fibers, Myelinated / ultrastructure
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Neural Conduction / physiology
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Peripheral Nervous System Diseases / chemically induced*
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Peripheral Nervous System Diseases / pathology*
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Recombinant Proteins
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Schwann Cells / metabolism*
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Sural Nerve / pathology
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Sural Nerve / ultrastructure
Substances
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HLA-DR Antigens
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Interferon Type I
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Recombinant Proteins