The most common inherited form of amyotrophic lateral sclerosis (ALS), a
neurodegenerative disease affecting adult motoneurons, is caused by dominant mutations …

This article reviews the clinical aspects of amyotrophic lateral sclerosis and potential
mechanisms of disease pathogenesis in the context of recent data supporting a major role …

In a large cohort of 1034 patients with the diagnosis of definite or probable amyotrophic
lateral sclerosis (ALS), the association of forced vital capacity (FVC) at baseline with (a) time …

Recent studies suggest that microglia over‐expressing mutant human superoxide dismutase
(mSOD1G93A) may contribute to motoneuron death in a transgenic mouse model of familial …

Recent studies suggest that motor neuron (MN) death may be non-cell autonomous, with
cell injury mediated by interactions involving non-neuronal cells, such as microglia and …

Background Studies have demonstrated that the current US guidelines based on American
College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort Equations …

Objective In order to define the predictors of prolonged survival available at the time of first
examination we performed a historical cohort study of amyotrophis sclerosis (ALS) patients …

We have used quantitative 2D gel electrophoresis to analyze serum proteins from 422
patients with neurodegenerative diseases and normal individuals in an unbiased approach …

Background: Amyotrophic lateral sclerosis (ALS), an inexorably progressive motoneuron
disease, is accompanied by significantly increased markers of inflammation. These …

Background In recent years, considerable effort has been made to improve the treatment of
patients with amyotrophic lateral sclerosis (ALS). However, despite the increased use of …