The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-
inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation …

Learning incorporates a broad range of complex procedures. Machine learning (ML) is a
subdivision of artificial intelligence based on the biological learning process. The ML …

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

Studies of grip strength typically examine maximum force during a single repetition, but this
type of exertion is relatively rare in the workplace, where tasks frequently involve repeated …

A novel series of quinoline isoxazole BET family bromodomain inhibitors are discussed.
Crystallography is used to illustrate binding modes and rationalize their SAR. One member, I …

Through their function as epigenetic readers of the histone code, the BET family of
bromodomain-containing proteins regulate expression of multiple genes of therapeutic …

The Arabic word “haboob,” meaning “strong wind,” describes a weather phenomenon
characterized by immense walls of blowing sand and dust. Common to many parts of the …

Synthetic modifications on a 6-furanylquinazoline scaffold to optimize the dual ErbB-1/ErbB-
2 tyrosine kinase inhibition afforded consistent SAR whereby a 4-(3-fluorobenzyloxy)-3 …

The discovery and development of new drugs are vital if we are to improve and expand
treatment options available to improve outcomes for patients. Overall, therapeutic strategies …

Background Stromal cell-derived factor 1 (SDF-1 or CXCL12) is chemotaxic for CXCR4
expressing bone marrow-derived cells. It functions in brain embryonic development and in …