The Arctic climate is changing. Permafrost is warming, hydrological processes are changing
and biological and social systems are also evolving in response to these changing …

Cancer is a disease of aging and, as the world's population ages, the number of older
persons with cancer is increasing and will make up a growing share of the oncology …

Biofilms are communal structures of microorganisms encased in an exopolymeric coat that
form on both natural and abiotic surfaces and have been associated with a variety of …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …

The elucidation of breast cancer subgroups and their molecular drivers requires integrated
views of the genome and transcriptome from representative numbers of patients. We present …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Calorie restriction extends lifespan and produces a metabolic profile desirable for treating
diseases of ageing such as type 2 diabetes,. SIRT1, an NAD+-dependent deacetylase, is a …

A major challenge in predicting Earth's future climate state is to understand feedbacks that
alter greenhouse-gas forcing. Here we synthesize field data from arctic Alaska, showing that …

Despite contributing to healthy diets for billions of people, aquatic foods are often
undervalued as a nutritional solution because their diversity is often reduced to the protein …