Leishmania species: models of intracellular parasitism
J Alexander, AR Satoskar… - Journal of cell …, 1999 - journals.biologists.com
Leishmania species are obligate intracellular parasites of cells of the macrophage-dendritic
cell lineage. Indeed, the ability to survive and multiply within macrophages is a feature of a …
cell lineage. Indeed, the ability to survive and multiply within macrophages is a feature of a …
Leishmaniasis: clinical syndromes and treatment
BS Mcgwire, AR Satoskar - QJM: An International Journal of …, 2014 - academic.oup.com
Leishmaniasis is a global term for cutaneous and visceral anthroponotic and zoonotic
diseases caused by the vector-borne parasites of the genus Leishmania. These diseases …
diseases caused by the vector-borne parasites of the genus Leishmania. These diseases …
[HTML][HTML] Mechanisms of cellular invasion by intracellular parasites
DM Walker, S Oghumu, G Gupta, BS McGwire… - Cellular and molecular …, 2014 - Springer
Numerous disease-causing parasites must invade host cells in order to prosper.
Collectively, such pathogens are responsible for a staggering amount of human sickness …
Collectively, such pathogens are responsible for a staggering amount of human sickness …
Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells
SJ Szabo, BM Sullivan, C Stemmann, AR Satoskar… - Science, 2002 - science.org
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage
commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 …
commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 …
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
JA Dubovsky, KA Beckwith, G Natarajan… - Blood, The Journal …, 2013 - ashpublications.org
Given its critical role in T-cell signaling, interleukin-2–inducible kinase (ITK) is an appealing
therapeutic target that can contribute to the pathogenesis of certain infectious, autoimmune …
therapeutic target that can contribute to the pathogenesis of certain infectious, autoimmune …
Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis
M Bozza, AR Satoskar, G Lin, B Lu… - The Journal of …, 1999 - rupress.org
To study the biologic role of migration inhibitory factor (MIF), a pleiotropic cytokine, we
generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of …
generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of …
The composition and signaling of the IL-35 receptor are unconventional
LW Collison, GM Delgoffe, CS Guy, KM Vignali… - Nature …, 2012 - nature.com
Abstract Interleukin 35 (IL-35) belongs to the IL-12 family of heterodimeric cytokines but has
a distinct functional profile. IL-35 suppresses T cell proliferation and converts naive T cells …
a distinct functional profile. IL-35 suppresses T cell proliferation and converts naive T cells …
Development of chronic colitis is dependent on the cytokine MIF
YP De Jong, AC Abadia-Molina, AR Satoskar… - Nature …, 2001 - nature.com
The cytokine macrophage-migration inhibitory factor (MIF) is secreted by a number of cell
types upon induction by lipopolysaccharide (LPS). Because colitis is dependent on interplay …
types upon induction by lipopolysaccharide (LPS). Because colitis is dependent on interplay …
Toll‐like receptor (TLR)‐2 and TLR‐4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury
Activation of macrophages via toll‐like receptors (TLRs) is important for inflammation and
host defense against pathogens. Recent data suggest that non‐pathogenic molecules …
host defense against pathogens. Recent data suggest that non‐pathogenic molecules …
Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon γ–producing Th1 cells
AL Wurster, VL Rodgers, AR Satoskar… - The Journal of …, 2002 - rupress.org
The cytokine potential of developing T helper (Th) cells is directly shaped both positively and
negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the …
negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the …