AIM: Of the many biological targets of oxidative stress, lipids are the most involved class of
biomolecules. Lipid oxidation gives rise to a number of secondary products …

Making sense of rapidly evolving evidence on genetic associations is crucial to making
genuine advances in human genomics and the eventual integration of this information in the …

Myeloma is a malignant proliferation of monoclonal plasma cells. Although morphologically
similar, several subtypes of the disease have been identified at the genetic and molecular …

Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples …

We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces
pombe), which contains the smallest number of protein-coding genes yet recorded for a …

The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …

Background Few data exist on the comparative safety and immunogenicity of different
COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection …

The doxorubicin-selected lung cancer cell line H69AR is resistant to many
chemotherapeutic agents. However, like most tumor samples from individuals with this …

Background CARTITUDE-1 aimed to assess the safety and clinical activity of ciltacabtagene
autoleucel (cilta-cel), a chimeric antigen receptor T-cell therapy with two B-cell maturation …

Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective …