Lennox–Gastaut Syndrome (LGS) is a category of severe, disabling epilepsy, characterized
by frequent, treatment-resistant seizures, and cognitive impairment. Electroencephalography …

Objective Prior uncontrolled studies have reported seizure reductions following deep brain
stimulation (DBS) in patients with Lennox–Gastaut syndrome (LGS), but evidence from …

Objective Deep brain stimulation (DBS) can reduce seizures in Lennox–Gastaut syndrome
(LGS). However, little is known about the optimal target and whether efficacy depends on …

Objectives Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) is an
emerging treatment for multiple brain diseases, including the drug-resistant epilepsy Lennox …

Summary Objective Lennox‐Gastaut syndrome (LGS) is a severe epilepsy phenotype with
characteristic electroclinical features despite diverse etiologies. We previously found …

Objective To identify brain regions underlying interictal generalized paroxysmal fast activity
(GPFA), and their causal interactions, in children and adults with Lennox-Gastaut syndrome …

One-third of people with epilepsy have generalized onset seizures, 1, 2 which appear to
begin in both hemispheres simultaneously on scalp electroencephalography (EEG). This …

Bottom-of-sulcus dysplasia (BOSD) is increasingly recognized as a cause of drug-resistant,
surgically-remediable, focal epilepsy, often in seemingly MRI-negative patients. We describe …

Abstract Introduction Lennox Gastaut syndrome (LGS) can be conceptualised as a
“secondary network epilepsy”, in which the shared electroclinical manifestations reflect …

Objective We aimed to assess the roles of the cortex and thalamus (centromedian nucleus
[CM]) during epileptic activity in Lennox‐Gastaut syndrome (LGS) patients undergoing deep …