Hypoxia, a state of low oxygen, is a common feature of solid tumors and is associated with
disease progression as well as resistance to radiotherapy and certain chemotherapeutic …

This review examines the vast catalytic and therapeutic potential offered by type I (ie oxygen-
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …

Small molecule covalent kinase inhibitors (CKIs) have entered a new era in drug discovery,
which have the advantage for sustained target inhibition and high selectivity. An increased …

Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as celts in
this environment often survive radiation and chemotherapy. In this report we describe how …

Hypoxic tumors are known to be more malignant, to be more likely to metastasize, and to
have a poor prognosis. They are also radio-and chemoresistant. For this reason, it is …

Background Changes in the microbial populations on the skin of animals have traditionally
been evaluated using conventional microbiology techniques. The sequencing of bacterial …

Purpose: Hypoxia is a characteristic of solid tumors and a potentially important therapeutic
target. Here, we characterize the mechanism of action and preclinical antitumor activity of a …

Abstract TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-
isophosphoramide mustard currently undergoing clinical evaluation. Here, we describe …

PR-104, currently in phase II clinical trials, is a phosphate ester pre-prodrug which is
converted in vivo to its cognate alcohol, PR-104A, a prodrug designed to exploit tumor …

UPDATED! Enhanced breed predisposition information demonstrates in which dogs and
cats dermatologic conditions are more likely to occur. NEW! Pattern approach dermatology …