User profiles for "author:Akihiro Sugai"

Akihiro Sugai

Brain Research Institute, Niigata University
Verified email at bri.niigata-u.ac.jp
Cited by 314

Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43

A Koyama, A Sugai, T Kato, T Ishihara… - Nucleic acids …, 2016 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder. In motor neurons of
ALS, TAR DNA binding protein-43 (TDP-43), a nuclear protein encoded by TARDBP, is …

Japanese amyotrophic lateral sclerosis patients with GGGGCC hexanucleotide repeat expansion in C9ORF72

T Konno, A Shiga, A Tsujino, A Sugai, T Kato… - Journal of Neurology …, 2013 - jnnp.bmj.com
Background A GGGGCC hexanucleotide repeat expansion in C9ORF72 occurs on a
chromosome 9p21 locus that is linked with frontotemporal dementia (FTD) and amyotrophic …

[HTML][HTML] Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model

T Kato, R Manabe, H Igarashi… - The Journal of …, 2021 - Am Soc Clin Investig
Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to
arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and …

Nipah and Hendra virus nucleoproteins inhibit nuclear accumulation of signal transducer and activator of transcription 1 (STAT1) and STAT2 by interfering with their …

A Sugai, H Sato, I Takayama, M Yoneda… - Journal of virology, 2017 - Am Soc Microbiol
ABSTRACT Henipaviruses, such as Nipah (NiV) and Hendra (HeV) viruses, are highly
pathogenic zoonotic agents within the Paramyxoviridae family. The phosphoprotein (P) …

Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation

A Sugai, T Kato, A Koyama, Y Koike, T Konno… - Neurobiology of …, 2019 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
accumulation of fragmented insoluble TDP-43 and loss of TDP-43 from the nucleus …

[HTML][HTML] Phosphorylation of measles virus phosphoprotein at S86 and/or S151 downregulates viral transcriptional activity

A Sugai, H Sato, M Yoneda, C Kai - FEBS letters, 2012 - Elsevier
Measles virus phosphoprotein (P protein) is a cofactor of the viral RNA polymerase (L
protein) that associates with the nucleoprotein–RNA complex to support viral transcription …

[HTML][HTML] Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex

Y Koike, A Sugai, N Hara, J Ito, A Yokoseki… - Communications …, 2021 - nature.com
In amyotrophic lateral sclerosis (ALS), TAR DNA-binding protein 43 (TDP-43), which is
encoded by TARDBP, forms aggregates in the motor cortex. This aggregate formation may …

[HTML][HTML] The nucleocapsid protein of measles virus blocks host interferon response

I Takayama, H Sato, A Watanabe, M Omi-Furutani… - Virology, 2012 - Elsevier
Measles virus (MV) belongs to the genus Morbillivirus of the family Paramyxoviridae. A
number of paramyxoviruses inhibit host interferon (IFN) signaling pathways in host immune …

[HTML][HTML] Recombinant SLAMblind measles virus is a promising candidate for nectin-4-positive triple negative breast cancer therapy

T Fujiyuki, Y Amagai, K Shoji, T Kuraishi… - Molecular Therapy …, 2020 - cell.com
One of the most refractory breast cancer types is triple negative (TN) breast cancer, in which
cells are resistant to both hormone and Herceptin treatments and, thus, often cause …

Peroxiredoxin 1 is required for efficient transcription and replication of measles virus

A Watanabe, M Yoneda, F Ikeda, A Sugai… - Journal of …, 2011 - Am Soc Microbiol
Measles is a highly contagious human disease caused by the measles virus (MeV). In this
study, by proteomic analysis, we identified peroxiredoxin 1 (Prdx1) as a host factor that binds …