A neuroprotective role for adenosine is commonly assumed. Recent studies revealed that
adenosine may unexpectedly, under certain circumstances, have the opposite effects …

This review summarizes recent developments that have contributed to understand how
adenosine receptors, particularly A2A receptors, modulate brain injury in various animal …

Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those
that did used very high concentrations of caffeine, whereas the brain concentrations attained …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of …

We assessed the geographical distribution of C9orf72 G 4 C 2 expansions in a pan‐E
uropean frontotemporal lobar degeneration (FTLD) cohort (n= 1,205), ascertained by the E …

Background Dementia and cognitive impairment associated with aging are a major medical
and social concern. Neuropsychological testing is a key element in the diagnostic …

Objective: To examine the association between caffeine intake, cognitive decline, and
incident dementia in a community-based sample of subjects aged 65 years and over …

Three sets of research criteria are available for diagnosis of Alzheimer's disease in subjects
with mild cognitive impairment: the International Working Group-1, International Working …

The heterogeneity of neurodegenerative diseases is a key confound to disease
understanding and treatment development, as study cohorts typically include multiple …

Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the
diagnostic workup of several neurological brain diseases. Reluctance to perform the …