INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Abstract Knowledge of the distributions and functions of native m1–m5 muscarinic
acetylcholine receptors in tissues is limited. To characterize the family of m1–m5 proteins …

Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare …

Abstract The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide
association study of late-onset Alzheimer disease using a three-stage design consisting of a …

The organization of projections from the cholinergic neurons of the basal forebrain to
neocortex and associated structures was investigated in the rhesus monkey with the help of …

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1 …

The cellular and subcellular distributions of the glutamate transporter subtypes EAACl, CLT-
1, and CIAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize …

The global endemic of cardiovascular diseases calls for improved risk assessment and
treatment. Here, we describe an association between myocardial infarction (MI) and a …

The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in
synaptosomal high‐affinity glutamate transport have been observed. In experimental …