[HTML][HTML] Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders
A Schneider, M Simons - Cell and tissue research, 2013 - Springer
The intercellular transfer of misfolded proteins has received increasing attention in various
neurodegenerative diseases characterized by the aggregation of specific proteins, as …
neurodegenerative diseases characterized by the aggregation of specific proteins, as …
Interorganellar communication
Signals originating from chloroplasts and mitochondria modulate nuclear gene expression
(retrograde signalling). Relevant signals are derived from the pool of reactive oxygen …
(retrograde signalling). Relevant signals are derived from the pool of reactive oxygen …
[HTML][HTML] Tau-based treatment strategies in neurodegenerative diseases
A Schneider, E Mandelkow - Neurotherapeutics, 2008 - Elsevier
Neurofibrillary tangles are a characteristic hallmark of Alzheimer's and other
neurodegenerative diseases, such as Pick's disease (PiD), progressive supranuclear palsy …
neurodegenerative diseases, such as Pick's disease (PiD), progressive supranuclear palsy …
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
JC Augustinack, A Schneider, EM Mandelkow… - Acta …, 2002 - Springer
Microtubule associated protein tau is abnormally phosphorylated in Alzheimer's disease
(AD) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs). We …
(AD) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs). We …
[HTML][HTML] Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte–neuron communication
C Frühbeis, D Fröhlich, WP Kuo, J Amphornrat… - PLoS …, 2013 - journals.plos.org
Reciprocal interactions between neurons and oligodendrocytes are not only crucial for
myelination, but also for long-term survival of axons. Degeneration of axons occurs in …
myelination, but also for long-term survival of axons. Degeneration of axons occurs in …
ARAMEMNON, a novel database for Arabidopsis integral membrane proteins
R Schwacke, A Schneider, E van der Graaff… - Plant …, 2003 - academic.oup.com
A specialized database (DB) for Arabidopsis membrane proteins, ARAMEMNON, was
designed that facilitates the interpretation of gene and protein sequence data by integrating …
designed that facilitates the interpretation of gene and protein sequence data by integrating …
[HTML][HTML] Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial
CJ Mummery, A Börjesson-Hanson, DJ Blackburn… - Nature medicine, 2023 - nature.com
Tau plays a key role in Alzheimer's disease (AD) pathophysiology, and accumulating
evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT …
evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT …
Transcription analysis of Arabidopsis membrane transporters and hormone pathways during developmental and induced leaf senescence
E van der Graaff, R Schwacke, A Schneider… - Plant …, 2006 - academic.oup.com
A comparative transcriptome analysis for successive stages of Arabidopsis (Arabidopsis
thaliana) developmental leaf senescence (NS), darkening-induced senescence of individual …
thaliana) developmental leaf senescence (NS), darkening-induced senescence of individual …
[HTML][HTML] The release and trans-synaptic transmission of Tau via exosomes
Y Wang, V Balaji, S Kaniyappan, L Krüger… - Molecular …, 2017 - Springer
Background Tau pathology in AD spreads in a hierarchical pattern, whereby it first appears
in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding …
in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding …
Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution
P Friedhoff, A Schneider, EM Mandelkow… - Biochemistry, 1998 - ACS Publications
Alzheimer's disease is characterized by the progressive deposition of two types of fibers in
the affected brains, the amyloid fibers (consisting of the Aβ peptide, generating the amyloid …
the affected brains, the amyloid fibers (consisting of the Aβ peptide, generating the amyloid …