A series of human and animal investigations has suggested that altered expression and
function of the α7-nicotinic cholinergic receptor may be responsible for the auditory sensory …

In an effort to reveal susceptibility genes, schizophrenia research has turned to the
endophenotype strategy. Endophenotypes are characteristics that reflect the actions of …

Sensory gating abnormalities are an early clinical symptom of schizophrenia, and are
characterized by a decrease in the brain's normal ability to inhibit the response to …

Inheritance of a defect in a neuronal mechanism that regulates response to auditory stimuli
was studied in nine families with multiple cases of schizophrenia. The defect, a decrease in …

Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5–1%, with high
heritability (80–85%) and complex transmission. Recent studies implicate rare, large, high …

Context The α7 nicotinic acetylcholine receptor gene, CHRNA7, is associated with genetic
transmission of schizophrenia and related cognitive and neurophysiological sensory gating …

Genes disrupted in schizophrenia may be revealed by de novo mutations in affected
persons from otherwise healthy families. Furthermore, during normal brain development …

Background The α7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) has
been implicated as a candidate gene for schizophrenia, and for an auditory sensory …

Objective: Nicotinic acetylcholine receptors are possible therapeutic targets for
schizophrenia, as shown by neurobiological and molecular evidence for deficiencies in …

Objective: To evaluate previously reported associations of copy number variants (CNVs)
with schizophrenia and to identify additional associations, the authors analyzed CNVs in the …