User profiles for "author:Audrey Low"
Audrey LowUniversity of Cambridge Verified email at medschl.cam.ac.uk Cited by 655 |
Inflammation and cerebral small vessel disease: a systematic review
Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …
disease (SVD). However, the underlying mechanisms and causative pathways remain …
Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice
TP Prakash, MJ Graham, J Yu, R Carty… - Nucleic acids …, 2014 - academic.oup.com
Triantennary N-acetyl galactosamine (GalNAc, GN3), a high-affinity ligand for the hepatocyte-
specific asialoglycoprotein receptor (ASGPR), enhances the potency of second-generation …
specific asialoglycoprotein receptor (ASGPR), enhances the potency of second-generation …
Rate of, and risk factors for, white matter hyperintensity growth: a systematic review and meta-analysis with implications for clinical trial design
Background White matter hyperintensities (WMHs) are a highly prevalent MRI marker of
cerebral small vessel disease (SVD), which predict stroke and dementia risk, and are being …
cerebral small vessel disease (SVD), which predict stroke and dementia risk, and are being …
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
W Shen, CL De Hoyos, MT Migawa, TA Vickers… - Nature …, 2019 - nature.com
The molecular mechanisms of toxicity of chemically modified phosphorothioate antisense
oligonucleotides (PS-ASOs) are not fully understood. Here, we report that toxic gapmer PS …
oligonucleotides (PS-ASOs) are not fully understood. Here, we report that toxic gapmer PS …
Risk of solid cancer in patients exposed to anti-tumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid …
Background Patients with rheumatoid arthritis (RA) have an increased risk of certain solid
cancers, in particular lung cancer, compared to the general population. Treatment with …
cancers, in particular lung cancer, compared to the general population. Treatment with …
Relationship between exposure to tumour necrosis factor inhibitor therapy and incidence and severity of myocardial infarction in patients with rheumatoid arthritis
ASL Low, DPM Symmons, M Lunt, LK Mercer… - Annals of the …, 2017 - ard.bmj.com
Objectives Patients with rheumatoid arthritis (RA) are at increased risk of myocardial
infarction (MI) compared with subjects without RA, with the increased risk driven potentially …
infarction (MI) compared with subjects without RA, with the increased risk driven potentially …
[PDF][PDF] Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy
AP Lieberman, Z Yu, S Murray, R Peralta, A Low… - Cell reports, 2014 - cell.com
Spinal and bulbar muscular atrophy (SBMA) is caused by the polyglutamine androgen
receptor (polyQ-AR), a protein expressed by both lower motor neurons and skeletal muscle …
receptor (polyQ-AR), a protein expressed by both lower motor neurons and skeletal muscle …
Risk of cancer in patients receiving non-biologic disease-modifying therapy for rheumatoid arthritis compared with the UK general population
LK Mercer, R Davies, JB Galloway, A Low… - …, 2013 - academic.oup.com
Objectives. To quantify the risk of cancer and compare it with that for the general population
in a modern cohort of UK patients with RA and to identify risk factors for cancer among this …
in a modern cohort of UK patients with RA and to identify risk factors for cancer among this …
Risk of lymphoma in patients exposed to antitumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid …
LK Mercer, JB Galloway, M Lunt, R Davies… - Annals of the …, 2017 - ard.bmj.com
Objectives Patients with rheumatoid arthritis (RA) are at increased risk of lymphoma
compared with the general population. There are concerns that tumour necrosis factor …
compared with the general population. There are concerns that tumour necrosis factor …
[HTML][HTML] DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing
K Nishina, W Piao, K Yoshida-Tanaka, Y Sujino… - Nature …, 2015 - nature.com
Antisense oligonucleotides (ASOs) are recognized therapeutic agents for the modulation of
specific genes at the post-transcriptional level. Similar to any medical drugs, there are …
specific genes at the post-transcriptional level. Similar to any medical drugs, there are …